伟哥是什么药很多人对这个问题比较感兴趣，下面让我们一起来看浼ユ涔，希望可以帮助到你。
浼??ユ???涔?????
??绌惰〃??锛?浼??ュ氨??不???锋?х??娈??ㄥ???涓?绉?????锛?涓昏???????涓?浜??????ㄧ?锋?ф???ㄤ?????互?瑰???崇?匡??捐???????讹?涔???涓?浜??锋?у?ㄦ???ㄤ????藉???璧凤??????瑰???у???介??纰??????躲????浠ワ???娲讳腑璁稿??锋?ч?戒?璐?拱杩?娆句??ュ??杩?琛??????涔???涓?浜??锋?ц????????ㄤ???瀵硅韩浣??戒??????烘???浼ゅ?锛???浠ユ??浠?缓璁?ぇ瀹跺?ㄤ娇?ㄨ?娆句??ュ?????跺??锛???濂芥????杩?姝ｈ????婚?㈠?????杩?琛?璐?拱锛?涔?瑕?????荤??????瀵煎??杩?琛????ㄣ??
浼??ョ?浠?
???
1 ?奸? 2 ?辨?????? 3 瑗垮?伴?ｉ??璇存??涔 3.1 ??????绉 3.2 ?辨????绉 3.3 浼??ョ?????? 3.4 ??绫 3.5 ???? 3.6 瑗垮?伴?ｉ????????浣?? 3.7 瑗垮?伴?ｉ??????唬?ㄥ??瀛 3.8 瑗垮?伴?ｉ??????搴?璇? 3.9 瑗垮?伴?ｉ????绂?蹇?璇? 3.10 娉ㄦ??浜?椤 3.11 瑗垮?伴?ｉ????涓?????搴? 3.12 瑗垮?伴?ｉ?????ㄦ??ㄩ?? 3.13 浼??ヤ??跺????╃???镐?浣?? 杩????涓???瀹????＄????变韩浜?瑗垮?伴?ｉ??????瀹广??涓烘?逛究??璇伙?涓???涓??? 瑗垮?伴?ｉ?? 宸茬????ㄦ?挎??负 浼?? 锛?? ?规??㈠???璨? 锛??? 浣跨?ㄥ?娉ㄦ?瑰?灞??1 ?奸?
w?i g?
2 ?辨??????
Viagra
3 浼??ヨ???涔
3.1 ??????绉
浼???/p>
3.2 ?辨????绉
Sildenafil
3.3 浼??ョ??????
涓??惧?????妾??稿???扮撼???瑗垮?伴?ｉ??
3.4 ??绫
娉?灏跨郴缁???? > 娌荤???锋?у??璧峰???介??纰???/p>
3.5 ????
????锛?姣????????5mg??50mg??100mg??
3.6 浼??ョ??????浣??
浼??ヤ负??７?搁??凤?cGMP锛??瑰?????纾烽?镐????讹?PDE5锛??????╂?ф???惰?????不??ED???ｆ?????┿??姝ｅ父浜 *** ??璧风???????哄?舵???? *** 杩?绋?涓????涓?姘у??姘??NO锛?锛??????俱??涓?姘у??姘??娲 *** 娴风坏浣?骞虫???缁?????楦??烽?哥?????讹?瀵艰??GMP姘村钩??楂?锛?浣垮?娴风坏浣???骞虫????惧?锛?娴风坏绐︽?╁?锛?琛?娑叉??ヨ??浣 *** ??璧枫????璧峰???介??纰????ｈ??涓昏????浜? *** 娴风坏浣?骞虫????惧???纰???浼??ュ?绂讳?浜烘捣缁典????存?ユ?惧?浣????浣??藉???杩????舵捣缁典?????PDE5瀵?GMP????瑙ｏ?浠???澧?寮轰?姘у??姘???浣??ㄣ??褰?? *** 寮?璧峰??ㄤ?姘у??姘????炬?讹?浼??ユ????DE5锛??????娴风坏浣???cGMP姘村钩锛??惧?娴风坏浣?骞虫???锛?琛?娑叉??ユ捣缁典???????绌惰〃????璧峰??搴?????????琛?娴?娴?搴︾??澧?????澧?寮猴?????????缁?h锛?浣?杈?2h?跺急锛???浣?澶?瀹?楠??剧ず浼??ュ?PDE5?锋??楂????╂?э?杩?绉????╂?т??ㄦ??DE1??80澶?????PDE2??PDE4??700澶?????PDE3??4000?????变?PDE3涓?蹇????剁缉?????у?舵???筹?蹇???涓?瀛???DE5锛?????浼??ユ??姝ｆ?ц????浣????涓??存?ュ奖??蹇????剁缉???姐??浣?浼??ュ??娇浣?寰????绠¤??寮?锛?澶у????锛?100mg锛??ｆ???跺????村?т?琛???涓???[骞冲????澶ч??骞?1.12/0.73kPa锛?8.4/5.5mmHg锛?]锛?涓???????1锝?2h琛???涓????????撅???琛????搴﹀嘲?兼?讹??ф椿?ㄥ???借???蹇???浜?浠躲??浼??ュ?PDE5?????╂?т??ㄤ????PDE6??10??锛???PDE6????ㄤ?瑙?缃???涓???涓?绉??讹???姝や??ュ?ㄩ???????楂?琛????搴︽?跺???藉?璧疯?茶?寮?甯搞???や汉娴风坏浣?骞虫???澶?锛??ㄨ?灏??裤??琛?绠°??????骞虫???浠ュ??楠ㄩ?????涔????颁?娴?搴︾??PDE5瀛??ㄣ??浼??ュ???介??杩?瀵硅?浜?缁?缁?涓?DE5?????惰??澧?寮烘??琛?灏??胯????锛?浣?澶?瀹?楠?锛??????惰?灏??胯???褰㈡??锛?浣???瀹?楠?锛?浠ュ????寮??ㄥ?磋?绠＄??浣????浣???瀹?楠?锛???
3.7 浼??ョ????唬?ㄥ??瀛
浼??ュ?ｆ?????告?惰???锛?10锝?40min璧锋??锛?缁?瀵圭???╁?╃?ㄥ害绾︿负40%??绌鸿?瑰?ｆ??30锝?120min??杈捐????搴﹀嘲?硷?cmax锛?锛?椁????ｆ??90锝?180min杈?max???ュ悍蹇??胯???????ｆ??100mg锛?24h??琛????搴︾害涓?ng/ml锛?cmax涓?40ng/ml???????藉?甯搞??涓ラ???惧???戒??ㄦ??65宀?浠ヤ???骞翠汉?ㄨ?????茬嚎涓??㈢Н锛?AUC锛???楂???浼??ュ???朵富瑕?寰???唬璋?骇?╋?N?荤?插?哄???╋???绾︽??96%涓?琛?娴????界???锛????界?????涓????╂?绘?搴︽???炽??缁?缁???甯???ソ锛???甯?瀹圭Н锛?Vd锛?涓?05L??浼??ヤ富瑕???杩???????寰??浣??剁????茬?P450 3A4锛?CYP 3A4锛?涓昏???寰?锛???缁????茬?P450 2C9锛?CYP 2C9锛?娆¤???寰?锛?娓??ゃ???朵富瑕?浠ｈ阿浜х?╋?N?荤?插?哄???╋??锋??涓?浼??ョ?镐技??PDE???╂?э??惰?娴?娴?搴︾害涓轰??ョ??40%锛???姝や??ョ??????浣??ㄥぇ绾︽??20%?ヨ????朵唬璋?骇?┿??浼??ュ???朵唬璋?骇?╃??娑??ゅ??琛版??绾︿负4h锛?缁???????80%涓昏?浠ヤ唬璋?骇?╃??褰㈠?缁?绮?究??娉?锛?13%缁??炬??娉????ュ悍蹇??胯????????90min锛?? *** 涓??寰?浼??ョ????涓?瓒崇???????0.001%??
3.8 浼??ョ????搴?璇?
?ㄤ?娌荤?? *** ??璧峰???介??纰?锛?ED锛???
3.9 浼??ョ??绂?蹇?璇?
1.瀵逛??ヨ???????
2.姝ｅ?ㄤ娇?ㄧ??哥??娌广??纭????????朵??????虹??哥??????
3.10 娉ㄦ??浜?椤
1.?????1锛??茬?瑙?缃????????朵?瑙?缃????稿舰???ｈ??锛???灏??版?ｈ?????芥??瑙?缃???纾烽?镐????剁????浼??у?哄??寮?甯革???锛?2锛???杩?6涓??????惧????蹇???姊?姝汇??????涓???浼??????存??у?寰?澶卞父?ｈ????锛?3锛?浣?琛?????楂?琛?????蹇???琛扮???缂鸿??у??????ｈ????锛?4锛??鸿??х?剧????澶?浜?娑????ф??℃椿?ㄦ?????ｈ????锛?5锛????璧 *** 寮?甯稿??璧风???剧???ｈ??锛?濡??板舰缁????ц传琛???澶????ч?楂??ゃ???借???锛???锛?6锛? *** 瑙ｅ???稿舰??锛?濡? *** 寮??层?? *** 娴风坏浣?绾ょ淮???ф??纭??锛???
2.???╁??跨???褰卞?? 浼??ヤ????ㄤ??跨?锛?灏ゅ?舵???扮???匡???
3.???╁???浜虹??褰卞?? ????绌惰〃??锛??ュ悍??骞村??胯??锛?涓?灏?浜?65宀?锛?瀵逛??ョ??娓??ょ????浣?锛??茬嚎涓??㈢Н澧???40%???翠?琛????搴﹁?楂????藉???涓?????搴?锛???浼??ヨ捣濮?????搴???灏???
4.???╁?濡?濞???褰卞?? 缇??借??????椋???绠＄??灞?锛?FDA锛?瀵逛??ョ??濡?濞?瀹??ㄦ?у??绾т负B绾с??
5.???╁??轰钩??褰卞?? 浼??ユ???﹂??涔虫???娉?灏?涓???纭???
6.浼??ヤ????ㄤ?濡?濂炽??
7.缁?浜?浼??ユ不??ED?????讹?搴?瀵瑰?剁?稿?崇????杩?琛?娌荤????姝ゅ?锛??ㄦ病??? *** ?讹?浼??ョ???ㄨ??????涓?璧蜂??ㄣ??
8.浼??ュ?璧风??浠板?т?琛????????ч??浣???甯稿?澶у??版?ｈ????互涓?璁★?浣?浠?瑕?浠?缁?????杩?绉?琛?绠¤??寮???搴????︿?缁?浣?琛??????朵?蹇?琛?绠＄?剧???ｈ??甯︽?ヤ???????锛?灏ゅ?舵???ㄦ?ф椿?ㄦ?讹??ㄥ凡??蹇?琛?绠″?遍?╁??绱?瀛??ㄦ?讹??ф椿?ㄥ?蹇?????娼??ㄧ???遍?╋?????瀵瑰凡??蹇?琛?绠＄?剧?????ｈ??锛?涓?瀹?浣跨?ㄤ??ユ不????璧峰???介??纰???
9.?ㄦ?ф椿?ㄥ?濮??讹??ュ?虹?板?缁?????澶存?????跺?绛????讹?椤荤?姝㈡?ф椿?ㄣ??
10.?ㄨ????? *** ??缁???璧疯?杩?4h锛?搴?缁?浜??稿?娌荤??锛??ュ?甯稿??璧锋????板???跺???锛? *** 缁?缁????藉???版??瀹冲苟瀵艰?存案涔??х????璧峰???戒抚澶便??
11.?朵?娌荤????璧峰???介??纰????规?涓?浼??ュ???ㄧ??瀹??ㄦ?у???????у?寰???绌讹?????涓??ㄨ???????ㄨ????
12.?ｈ?????ㄤ??ュ??锛?浣??跺??互瀹??ㄥ?版???ㄧ??搁??被???╋?????灏?涓?娓?妤???
13.????绌惰〃??锛??ュ悍蹇??胯????娆″????澧???00mg锛?涓?????搴?涓?浣??????剁?镐技锛?浣???????澧?????褰??ㄨ??????讹?搴??规????瑕?????甯歌???????娉????变?浼??ヤ?琛?娴????界?????楂?锛?涓?涓?浠?灏夸腑娓??わ???姝よ?娑查????涓?浼?澧???娓??ょ????
3.11 浼??ョ??涓?????搴?
1.蹇?琛?绠＄郴缁?锛???????蹇???姊?姝汇??蹇?婧??х??姝汇??蹇???琛扮???蹇?寰?澶卞父??浣?琛????????鸿?????琛???褰㈡????涓?杩??у??ㄧ己琛??т?????楂?琛???绛?蹇?琛?绠′?????搴?浜?浠舵?ラ??锛?澶??板?????ㄦ?ф椿?ㄦ???存????缁????讹?涓????????ㄧ?ㄨ?????ф椿?ㄥ???板??惰?虫?板ぉ??锛????宠???灏????????ㄦ??????涓?涔?灏????琛??ф椿?ㄦ?躲??????灏???‘瀹?杩?浜???搴????︾?变??ョ?存?ュ?璧凤?杩????辨?ф椿?ㄣ???ｈ????蹇?琛?绠＄?跺?电?澶?绉???绱??卞??浣??ㄨ??寮?璧枫??
2.娑???绯荤?锛????虹?版???涓????7%锛????规郴锛?3%锛?锛????ｅ共???????????藉?伴?俱????????榻块??????ｈ??????椋?绠＄??????????缁????????????藉?甯搞???磋???鸿?绛??ラ????
3.琛?娑诧???璐?????界?????灏???涓???ラ????
4.浠ｈ阿/????娉?绯荤?锛?????椋???绯?灏跨?????ㄥ?存?ф按?裤??楂?灏块?歌?????浣?琛?绯???搴???楂???琛???绛??ラ????
5.?煎?哥郴缁?锛????虹?伴蓟濉?锛?4%锛?锛??????????藉??????榧荤????????绠＄????澶??般???冲?姐???煎?稿?伴?剧?涓???ラ????
6.娉?灏跨??娈?绯荤?锛????虹?板翱??????锛?3%锛?锛??????辩????澶?灏垮?澶???灏块???灏垮け绂???寮?甯 *** ????娈??ㄦ按?裤??缂轰?? *** 绛??ラ??锛?涔???寮?璧 *** ??璧锋?堕?村欢?匡?瓒?杩?4h锛???寮?甯稿??璧凤????у??璧疯?杩?6h锛???琛?灏跨?涓???ラ????
7.涓??㈢?缁?绯荤?锛????虹?板ご??锛?16%锛????╂??锛?2%锛?锛????辨?澶辫?????寮???杩?楂?????棰ゃ??绁?缁?????绁?缁?????????瑙?寮?甯搞???╂???????????﹁????澶辩???????°??澶?姊︺????灏?杩?缂?????瑙?杩???????????浣?绛?涓???ラ????
8.????楠ㄩ?绯荤?锛????宠???剧???????????????辨??????遍??????楠ㄧ????????????婊?????绛?涓???ラ????
9.???わ????虹?伴?㈤?ㄦ疆绾??10%锛??????癸?2%锛?锛????ㄩ夯?广????绾??х?辩?广???????????ゆ??°???ヨЕ?х???????ヨ?辨?х????绛?涓???ラ????
10.?硷????冲??╁ぇ??缁????????煎?鸿????藉???????煎共???肩??????????绾㈢?兼???奸?ㄥ??琛????奸?ㄧ?х?兼?????奸?ㄨ?胯??????杩??????煎????澧?楂???瑙?缃???琛?绠＄???????鸿????荤??浣??ョ???榛????ㄥ?存按?跨??ラ????杩????虹?拌交搴︾??涓?杩??ц?瑙?寮?甯革?3%锛?锛?涓昏?琛ㄧ?颁负瑙??╄?叉贰??????澧?寮恒??瑙??╂ā绯?浠ュ??澶?瑙???????瑙?瑙?涓уけ??瑙???涓???绛???
11.?筹????抽福???宠?????ラ????
12.?朵?锛?杩????虹?板?ㄨ韩??搴?锛?濡?浼?????涔??????肩??锛?濡??哥??锛???瀵?????杩?????搴?绛???
3.12 浼??ョ???ㄦ??ㄩ??
1.瀵瑰ぇ澶??版?ｈ??锛??ㄨ??????涓?0mg锛??ㄦ?ф椿?ㄥ??绾?h???????????????????? *** ??浣??ㄦ?ф椿?ㄥ??0.5锝?4h????浠讳??跺?????ㄥ??????轰????????????э?涓?澶╁???????25锝?100mg涔??磋??达?涓?澶╃?ㄨ???胯?杩?1娆°??锛?1锛??惧???戒??ㄦ?跺???? ?ㄨ??涓ラ???惧???戒??ㄨ??锛?????娓??ょ??灏?浜???绛?浜?30ml/min?讹?AUC??cmax??涔?????锛???璧峰?????涓?5mg??锛?2锛??????戒??ㄦ?跺?????ㄨ???????芥??瀹宠??锛?濡???纭????讹?AUC??cmax?????楂?84%??47%锛???璧峰?????涓?5mg??
2.??骞翠汉???? ?ㄨ??65宀?浠ヤ???浜虹??璧峰?????涓?5mg??
3.?朵??剧???跺???? 锛?1锛????舵???ㄥ己??缁????茬?P4503A4???跺????绾㈤??绱?????璧峰?????浠?5mg涓哄???锛?2锛?寤鸿?????IV???介?舵???跺?猴?濡??╂???ｉ?︼????ｈ??锛?姣?48h???ㄤ??ュ??????澶?涓?瓒?杩?25mg??
3.13 ???╃?镐?浣??
1.锛?1锛?涓?CYP450 3A4?舵???惰???濡???悍????浼??插悍????绾㈤??绱????CYP450?????瑰??ф???惰???濡?瑗垮???夸?锛????ㄦ?讹?浼??ョ??AUC??楂???娓??ょ????浣???锛?2锛?涓?HIV???介?舵???惰??濡?娌?濂??ｉ?︺???╂???ｉ?︼?Ritonavir锛?]?????浼??ョ??cmax??AUC澧?楂?锛???娌?濂??ｉ?﹀???╂???ｉ?︾ǔ???剁?????ㄥ?涓???褰卞????锛?3锛?涓?琚㈠?╁翱????淇??惧?╁翱?????????╂??插??浣??绘??????????娇浼??ョ??娲绘?т唬璋?骇?╋?N?荤?插?轰??ワ???AUC???????62%??102%锛?浣?杩?绉?褰卞????涓村???涔???锛?4锛?涓?CYP4503A4??璇卞????濡??╃?骞筹????ㄥ???介??浣?浼??ヨ?娴?姘村钩??锛?5锛?涓?CYP450 2C9???惰???濡??茶??：涓??层????娉???锛????ㄦ?讹???????剧?镐?浣??ㄣ??锛?6锛?涓?CYP450 2D6?舵???惰???濡????╂??缇??茶?哄?????????惰????涓???被????????????诲??被???╁???诲??被?╁翱????琛?绠＄揣寮?绱?杞??㈤?舵???跺???????????绘???绛??????瀵逛??ヨ???ㄥ???褰卞????
2.楂?琛????ｈ?????舵???ㄤ??ワ?100mg锛???姘ㄦ隘?板钩锛?5mg??10mg锛?锛?浠板?т??剁缉??骞冲??杩?涓?姝ラ??浣?1.06kPa锛?8mmHg锛?锛???寮???骞冲??杩?涓?姝ラ??浣?0.93kPa锛?7mmHg锛???
3.涓?伪??浣??绘????濡?澶?娌??????????????戒?寮?璧锋??浜??ｈ????浣?琛??????躲????姝わ?浼??ュ????濡?瓒?杩?25mg锛???涓?搴??ㄦ???ㄎ卞??浣??绘???h涔??????ㄣ??
4.涓????虹??搁??被???ㄦ?讹?浼??ュ??????DE5杩???褰卞??cGMP????瑙ｏ????戒娇琛?????搴︿???锛?搴?绂?姝㈠???ㄣ??
5.浣?澶?瀹?楠????颁??ュ???寮虹?????????浜虹被琛?灏??垮????浣??ㄣ??
6.涓???绱??扮???瀵归夯?????鸿??堕?寸??寤堕?挎??????浣????浣????琛?杩?绫讳技??浜轰???绌躲??
7.涓??垮?稿?规???????瀵瑰?鸿??堕?存病??褰卞????
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